Quantitative Analysis of Neuronal Polarization and Migration

We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility. To meet our high standards every day, we are looking forward to your scientific expertise at the Institute of Medical Physics and Biophysics. The Galic lab investigates how cells coordinate their shape, polarity, and movement using an interdisciplinary approach that combines cell biology, advanced microscopy, quantitative image analysis, and computational methods. Our research project, “Quantitative Analysis of Neuronal Polarization and Migration”, focuses on the molecular and cellular mechanisms underlying neuronal development in the human cerebral cortex. We aim to understand how extracellular signals regulate intracellular calcium signaling, cytoskeletal rearrangements, and neuronal migration. Using human stem cell-derived neurons, three-dimensional culture systems, and cortical organoids, we investigate how disruptions in these processes contribute to neurodevelopmental disorders, including lissencephaly – ideally with you on board!

• Investigating the molecular mechanisms regulating neuronal polarization and migration during cortical development
• Analyzing how neurotransmitter receptor composition and localization influence intracellular calcium signaling
• Examining the role of calcium signaling in cytoskeletal rearrangements and the establishment of neuronal polarity
• Conducting experiments using human stem cell-derived neurons, three-dimensional culture systems, and cortical organoids
• Applying advanced fluorescence microscopy and quantitative image analysis to study neuronal development
• Investigating the contribution of disrupted neuronal polarization and migration to neurodevelopmental disorders
• Contributing to the independent development and implementation of scientific research ideas

• Master's degree or equivalent qualification in biology, biomedicine, neuroscience, biophysics, or a related discipline
• Strong interest in developmental neuroscience, cell biology, and the molecular mechanisms of neuronal development
• Motivation to learn and apply advanced experimental and quantitative research techniques
• Previous experience in neuronal cell culture, fluorescence microscopy, or quantitative image analysis is an advantage but not required
• Curiosity, analytical thinking, and enthusiasm for independent scientific research
• Good English language and communication skills
• Enjoyment of working in an interdisciplinary and international research environment
• Applications should include a cover letter describing research interests and motivation, a current CV with academic transcripts, and contact details for at least two professional references.
• Due to the legal requirements of the German Measles Protection Act, employment with us is only possible with full vaccination protection against measles.